2'-Deoxy-4'-ethynyl-2-fluoroadenosine
CAS: 865363-93-5
Ref. 3D-ND45638
| 1mg | 255.00 € | ||
| 2mg | 399.00 € | ||
| 5mg | 569.00 € | ||
| 10mg | 847.00 € | ||
| 25mg | 1,593.00 € |
Product Information
- EFdA
2'-Deoxy-4'-ethynyl-2-fluoroadenosine (EFdA) is an analog of adenosine. EFdA is a potent inhibitor of HIV replication, and has been shown to be effective against other viruses such as influenza virus, herpes simplex virus, and vesicular stomatitis virus. EFdA was the first nucleoside analog to show antiviral activity in tissue culture against these viruses. This drug also inhibits the synthesis of mitochondrial rRNA and reduces the formation of mitochondrial DNA in human cells by inhibiting mitochondrial DNA polymerase γ. EFdA also prevents the binding of monoclonal antibodies to human B lymphocytes, which may be due to its steric interactions with plasma RNA. This drug is metabolized by cytochrome P450 2C8 and 2C9 into a variety of metabolites that are excreted in urine as glucuronides or sulfates. EFdA has a long
Chemical properties
Technical inquiry about: 3D-ND45638 2'-Deoxy-4'-ethynyl-2-fluoroadenosine
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