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CAS 865363-93-5

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2′-Deoxy-4′-C-ethynyl-2-fluoroadenosine

Description:
2′-Deoxy-4′-C-ethynyl-2-fluoroadenosine, commonly referred to as a modified nucleoside, is characterized by its structural modifications that enhance its stability and bioactivity. This compound features a deoxyribose sugar backbone, with a fluorine atom at the 2′ position and an ethynyl group at the 4′ position, which contribute to its unique chemical properties. The presence of the ethynyl group can improve the compound's resistance to enzymatic degradation, making it a valuable candidate in therapeutic applications, particularly in antiviral and anticancer research. The fluorine substitution can also influence the compound's binding affinity to biological targets, potentially enhancing its efficacy. As a nucleoside analog, it may interfere with nucleic acid synthesis, thereby impacting cellular processes. Overall, 2′-Deoxy-4′-C-ethynyl-2-fluoroadenosine represents a significant modification of adenosine, with potential implications in medicinal chemistry and drug development.
Formula:C12H12FN5O3
InChI:InChI=1S/C12H12FN5O3/c1-2-12(4-19)6(20)3-7(21-12)18-5-15-8-9(14)16-11(13)17-10(8)18/h1,5-7,19-20H,3-4H2,(H2,14,16,17)/t6-,7+,12+/m0/s1
InChI key:InChIKey=IKKXOSBHLYMWAE-QRPMWFLTSA-N
SMILES:NC1=C2C(N(C=N2)[C@@H]3O[C@](C#C)(CO)[C@@H](O)C3)=NC(F)=N1
Synonyms:
  • E2FDA
  • Adenosine, 2′-deoxy-4′-C-ethynyl-2-fluoro-
  • 4′-Ethynyl-2-fluoro-2′-deoxyadenosine
  • MK 8591
  • 2'-Deoxy-4'-ethynyl-2-fluoroadenosine
  • 4'-ethynyl-2-fluoro-2'-deoxyadenosine
  • 2′-Deoxy-4′-C-ethynyl-2-fluoroadenosine
  • Islatravir
  • Adenosine Impurity 22
  • 4'-ethynyl-2-fluoro-2'-deoxyadenosine EFDA E2FDA
  • See more synonyms
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