2'-Deoxy-5-formylcytidine
CAS: 137017-45-9
Ref. 3D-ND63556
| 1mg | 136.00 € | ||
| 2mg | 185.00 € | ||
| 5mg | 333.00 € | ||
| 10mg | 447.00 € | ||
| 25mg | 633.00 € |
Product Information
2'-Deoxy-5-formylcytidine is a nucleoside analog that is used as a chemotherapeutic agent. It is cytotoxic to cells by binding to DNA and preventing the synthesis of DNA, RNA, and protein. The drug has been shown to induce cellular senescence in human fibroblasts, which can be reversed by the addition of deuterium. 2'-Deoxy-5-formylcytidine also inhibits the production of reactive oxygen species (ROS) by inducing the expression of antioxidant enzymes such as superoxide dismutase 2 and glutathione peroxidase 1. The oxidation products are misincorporated into DNA strands, leading to intramolecular hydrogen bonds with cytosine bases. These modifications lead to denaturation of DNA and inhibition of transcription and replication.
2'-Deoxy-5-formylcytidine also interacts with oligodeoxynucleotides, which leads to misinc
Chemical properties
Technical inquiry about: 3D-ND63556 2'-Deoxy-5-formylcytidine
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