2'-Deoxy-4'-thiouridine

CAS: 134111-32-3

Ref. 3D-ND63588

Product Information

• Name: 2'-Deoxy-4'-thiouridine
• Brand: Biosynth
• Description: 2'-Deoxy-4'-thiouridine (2dT) is a synthetic purine nucleoside analogue that has antiviral activity against herpes simplex virus and hepatitis B virus. It is a lead compound for the development of therapeutic agents for human immunodeficiency virus type 1 and varicella, and it has potential applications in the treatment of renal toxicity. 2dT inhibits viral replication by inhibiting viral thymidine kinase, which converts 2dT to 2'-deoxy-4'-thioguanosine monophosphate (2'TGMP). The 2'TGMP inhibits intracellular phosphorylation reactions necessary for DNA synthesis and cell division. This inhibition leads to death of the infected cells.

Chemical properties

• Molecular weight: 244.27 g/mol
• Formula: C₉H₁₂N₂O₄S
• Purity: Min. 95%