5'-Ethylcarboxamidoadenosine

CAS: 35920-39-9

Ref. 3D-NE06155

Product Information

• Name: 5'-Ethylcarboxamidoadenosine
• Synonyms: 1-(6-Amino-9H-purin-9-yl)-1-deoxy-N-ethyl-b-D-ribofuranuronamideNECA5'-Ethylcarboxamido-D-adenosine, (2S,3R,5R)-5-(6-amino-9H-purin-9-yl)-N-ethyl-3,4-dihydroxytetrahydrofuran-2-carboxamide (non-preferred name), (2S,3S,4R)-5-(6-amino-9H-purin-9-yl)-N-ethyl-3,4-dihydroxytetrahydrofuran-2-carboxamide (non-preferred name), (2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-N-ethyl-3,4-dihydroxytetrahydrofuran-2-carboxamide (non-preferred name), 1-(6-Amino-9H-purin-9-yl)-1-deoxy-N-ethyl-beta-D-ribofuranuronamide, 1-(6-Amino-9H-purin-9-yl)-1-deoxy-N-ethyl-β-<span class="text-smallcaps">D</span>-ribofuranuronamide, 5'-N(Sup 6)-Ethylcarboxamidoadenosine, 5'-N-Ethylcarboxamidoadenosine, 5′-N⁶-Ethylcarboxamidoadenosine, 744-96, Adenosine 5′-ethylcarboxamide, Adenosine-5'-(N-ethylcarboxamide), D-Neca, beta-D-Ribofuranuronamide, 1-(6-amino-9H-purin-9-yl)-1-deoxy-N-ethyl-, β-<span class="text-smallcaps">D</span>-Ribofuranuronamide, 1-(6-amino-9H-purin-9-yl)-1-deoxy-N-ethyl-

Description

5'-Ethylcarboxamidoadenosine (5-ECA) is an adenosine receptor antagonist that is used as a radioligand to study the binding of adenosine and other nucleotides to their receptors. 5-ECA binds to the A3 receptor, which is a member of the G protein-coupled receptor family. This compound also inhibits platelet aggregation and has been shown to have anti-inflammatory effects in mice with colon cancer. 5-ECA was found to inhibit tumor growth in a mouse model system by suppressing IL-2 production and reducing levels of PGE2, an effect that may be due to inhibition of cyclase activity. 5-ECA can be used in vitro for studies on pluripotent cells because it does not affect their ability to differentiate.

• Brand: Biosynth

Chemical properties

• Molecular weight: 308.29 g/mol
• Formula: C₁₂H₁₆N₆O₄
• Purity: Min. 95%
• Color/Form: White Powder