Product Information
Name:2'-Epi-lamivudine
Synonyms:
- Lamivudine impurity B 4-Amino-1-[(2S,5S)-2-(hydroxymethyl)-1,3-oxathiol an-5-yl]-2(1H)-pyrimidinone(2S-trans)-4-Amino-1-[2-(hydroxymethyl)-1 ,3-oxathiolan -5-yl]-2(1H)-pyrimidinonetrans(-)-2-Hydroxymethyl-5-(cytosin-1-yl)-1 ,3-oxathiolane
Brand:Biosynth
Description:2'-Epi-lamivudine is a chiral, racemic mixture of the two enantiomers of lamivudine. The synthesis and purification of 2'-epi-lamivudine is achieved by using a chiralpak column to separate the optical isomers from each other and then an immunoaffinity column to remove the undesired enantiomer (the S-enantiomer). The final product is a mixture of both enantiomers in a 1:1 ratio, which has been shown to have antiviral activity against HIV.
2'-Epi-lamivudine has been shown to be more potent than its parent compound lamivudine and is less toxic. This antiviral agent inhibits HIV replication by inhibiting reverse transcriptase, which is an enzyme that synthesizes viral DNA from viral RNA. It also has anti-inflammatory properties that may be due to inhibition of prostaglandin synthesis.
2'-Epi-lamivudine has been shown to be more potent than its parent compound lamivudine and is less toxic. This antiviral agent inhibits HIV replication by inhibiting reverse transcriptase, which is an enzyme that synthesizes viral DNA from viral RNA. It also has anti-inflammatory properties that may be due to inhibition of prostaglandin synthesis.
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:229.26 g/mol
Formula:C8H11N3O3S
Purity:Min. 95%
InChI:InChI=1S/C8H11N3O3S/c9-5-1-2-11(8(13)10-5)6-4-15-7(3-12)14-6/h1-2,6-7,12H,3-4H2,(H2,9,10,13)/t6-,7-/m0/s1
InChI key:InChIKey=JTEGQNOMFQHVDC-BQBZGAKWSA-N
SMILES:Nc1ccn([C@@H]2CS[C@@H](CO)O2)c(=O)n1
Technical inquiry about: 2'-Epi-lamivudine
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