4'-C-Fluoroadenosine 5'-sulfamate

CAS: 24751-69-7

Ref. 3D-NF76155

Product Information

• Name: 4'-C-Fluoroadenosine 5'-sulfamate
• Synonyms: Nucleocidin4'-Fluoro-5'-O-sulfamoyladenosine, 24751-69-7, 4′-Fluoro-5′-O-sulfamoyladenosine, Adenosine, 4′-C-fluoro-, 5′-sulfamate, NSC 521007, Nucleocidin

Description

4'-C-Fluoroadenosine 5'-sulfamate is a molecule that inhibits protein synthesis by binding to the ribosomes of bacteria. It also has anti-angiogenic effects and can be used as an antimicrobial agent against staphylococci, streptococci, and mycobacteria. 4'-C-Fluoroadenosine 5'-sulfamate has minimal toxicity in humans and is not active against Saccharomyces cerevisiae or Escherichia coli. The optimum concentration for inhibiting protein synthesis in vitro was determined to be between 100 and 500 μM. This compound is inexpensive and can be synthesized from commercially available starting materials. In cell culture assays, this compound showed antimicrobial activity against staphylococci, streptococci, and mycobacteria with MIC values ranging from 0.03 to 1 mM.br>
4'-C-Fluoroadenosine 5'-s

• Brand: Biosynth

Chemical properties

• Molecular weight: 364.31 g/mol
• Formula: C₁₀H₁₃FN₆O₆S
• Purity: Min. 95%
• InChI: InChI=1S/C10H13FN6O6S/c11-10(1-22-24(13,20)21)6(19)5(18)9(23-10)17-3-16-4-7(12)14-2-15-8(4)17/h2-3,5-6,9,18-19H,1H2,(H2,12,14,15)(H2,13,20,21)
• InChI key: InChIKey=LTBCQBSAWAZBDF-UHFFFAOYSA-N
• SMILES: Nc1ncnc2c1ncn2C1OC(F)(COS(N)(=O)=O)C(O)C1O