Guanosine-5'-[(b,γ)-methyleno]triphosphate sodium salt

CAS: 13912-93-1

Ref. 3D-NG46689

Product Information

• Name: Guanosine-5'-[(b,γ)-methyleno]triphosphate sodium salt
• Synonyms: GMPPCPGppCp, 5'-Guanylylmethylenebisphosphonate, 5'-Guanylylmethylenediphosphonate, 5'-O-[(S)-hydroxy{[(R)-hydroxy(phosphonomethyl)phosphoryl]oxy}phosphoryl]guanosine, 5′-Guanylic acid, monoanhydride with methylenebis[phosphonic acid], 5′-Guanylic acid, monoanhydride with methylenediphosphonic acid, 5′-Guanylyl methylenediphosphonate, 5′-Guanylyl-β,γ-methylenediphosphate, Guanosine 5′-(β,γ-methylene)triphosphate, Guanylyl-β,γ-methylenediphosphonate, Phosphomethylphosphonic Acid-Guanylate Ester, Phosphonic acid, methylenedi-, monoanhydride with 5′-guanylic acid, β,γ-Methylene guanosine 5′-triphosphate, β,γ-Methylene-GTP, β,γ-Methyleneguanosine triphosphate, Guanosine 5'-monophosphate, monoanhydride with (phosphonomethyl)phosphonic acid

Description

Guanosine-5'-[(b,gamma)-methyleno]triphosphate sodium salt (GMPP) is an analog of guanosine triphosphate that is enzymatically inactivated by the enzyme kinesin. GMPP inhibits the polymerization of microtubules by binding to the kinesin molecule and preventing it from binding to tubulin. GMPP has been shown to inhibit sephadex g-100 chromatography and act as a competitive inhibitor for protein synthesis in vitro. GMPP has also been shown to have a fat cell differentiation effect which may be due to its ability to inhibit microtubule polymerization.

• Brand: Biosynth

Chemical properties

• Molecular weight: 521.21 g/mol
• Formula: C₁₁H₁₈N₅O₁₃P₃·xNa
• Purity: Min. 95 Area-%
• Color/Form: Powder