3'-O-Methylguanosine

CAS: 10300-27-3

Ref. 3D-NM06232

Product Information

• Name: 3'-O-Methylguanosine
• Synonyms: 2-Amino-9-[(2R,3R,4S,5R)-3-hydroxy-5-(hydroxymethyl)-4-methoxytetrahydrofuran-2-yl]-3,9-dihydro-6H-purin-6-one
• Brand: Biosynth
• Description: 3'-O-Methylguanosine is a nucleoside that is found in the guanine molecule and has been shown to have inhibitory properties against malignant brain tumors. 3'-O-Methylguanosine blocks the synthesis of DNA, RNA, and peptide hormones. It also inhibits the growth of erythromycin-resistant strains of bacteria. The kinetic data for 3'-O-Methylguanosine was obtained from experiments with leukemic mice and carcinoma cell lines. The enzyme glut1 regulates the rate of metabolism of 3'-O-Methylguanosine. It is metabolized by dehydroascorbic acid reductase to 3'-deoxyadenosine monophosphate (dAMP) and then to adenosine monophosphate (AMP). The optimum pH for this reaction is 7.3 at 37 degrees Celsius.

Chemical properties

• Molecular weight: 297.27 g/mol
• Formula: C₁₁H₁₅N₅O₅
• Purity: Min. 98 Area-%
• Color/Form: White Off-White Powder