1-(2'-O-4-C-Methylene-b-D-ribofuranosyl)guanine

CAS: 207131-16-6

Ref. 3D-NM08152

Product Information

• Name: 1-(2'-O-4-C-Methylene-b-D-ribofuranosyl)guanine
• Synonyms: LNA-G diolLNA-Guanosine
• Brand: Biosynth
• Description: 1-(2'-O-4-C-Methylene-b-D-ribofuranosyl)guanine is a nucleoside that is used in the synthesis of DNA. It is a novel, synthetic nucleoside that has been modified to contain a 2'-O-4-C methylene bridge and an additional ribose moiety at the 3' position. This modification increases the stability of the nucleotide, making it more resistant to degradation by phosphodiesterases. 1-(2'-O-4-C-Methylene-b-D-ribofuranosyl)guanine may be used as an antiviral agent against HIV and influenza A virus. The compound has also shown anticancer activities in mice with leukemia induced by busulfan.

Chemical properties

• Molecular weight: 295.25 g/mol
• Formula: C₁₁H₁₃N₅O₅
• Purity: Min. 95%
• InChI: InChI=1S/C11H13N5O5/c12-10-14-7-4(8(19)15-10)13-3-16(7)9-5-6(18)11(1-17,21-9)2-20-5/h3,5-6,9,17-18H,1-2H2,(H3,12,14,15,19)/t5-,6?,9+,11-/m0/s1
• InChI key: InChIKey=OZVMOEUWPMYRQU-FDCDAFTRSA-N
• SMILES: Nc1nc2c(ncn2[C@@H]2O[C@@]3(CO)CO[C@H]2C3O)c(=O)[nH]1