2'-O-Methyl-2-thiouridine
CAS: 113886-72-9
Ref. 3D-NM159407
| 2mg | 452.00 € | ||
| 5mg | 633.00 € | ||
| 10mg | 723.00 € | ||
| 25mg | 1,216.00 € |
Product Information
- 2′-O-Methyl-2-thiouridine
- Uridine, 2′-O-methyl-2-thio-
2'-O-Methyl-2-thiouridine is a modified nucleoside that is categorized as a mismatched nucleotide. It is found in RNA, where it replaces uridine and acts as a mismatch base. 2'-O-Methyl-2-thiouridine has been shown to stabilize duplex DNA against thermal denaturation by forming triplexes with complementary sequences. It also stabilizes dsDNA against hydrolysis by the enzyme ribonuclease H (RNase H) and has been used in the design of antisense therapeutics. Thermophilic bacteria use this molecule to synthesize their own thymine nucleotides, which are structurally similar to 2'-O-methyl-2-thiouridine. This modification prevents mismatches in their own dna and helps protect them from heat stress. The thermodynamic stability of this molecule has been calculated using an algorithm that takes into account the hybridization free energy, enthalpy change, entropy
Chemical properties
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