Product Information
ZD-4190 is a small molecule that blocks the function of angiogenic factors such as VEGF, PDGF, and FGF. It has been shown to have anti-angiogenic effects in animal models of solid tumours. ZD-4190 also inhibits the integrin receptor which mediates the uptake of these molecules by endothelial cells and promotes angiogenesis. This agent inhibits hydrogen bonding between the VEGF molecule and its receptor at the cell surface, thereby preventing activation of the angiogenic process. The microvessel density was significantly reduced in animals treated with ZD-4190, suggesting a reduction in tumor vascularization.
Chemical properties
Technical inquiry about: 3D-NRA59962 ZD-4190
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