Product Information
M-89 is a monoclonal antibody that targets fatty acid binding protein 4 (FABP4) and inhibits the uptake of lipids in muscle cells. M-89 has been shown to be clinically relevant for women with atherosclerotic cardiovascular disease and also for those who are obese. M-89 has shown some promise as a diagnostic tool for polymyositis, dermatomyositis, systemic lupus erythematosus, and other inflammatory muscle diseases. The experimental model system used to assess the efficacy of M-89 was a rat model of polymyositis induced by injection of an allergen into the thigh muscle. In this study, M-89 inhibited lipid uptake by blocking FABP4, which is located on the surface of muscle cells. This inhibition led to decreased levels of proinflammatory cytokines that are responsible for causing muscle damage.
Chemical properties
Technical inquiry about: 3D-NUD16542 M-89
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