GD1a-Ganglioside sodium

CAS: 12707-58-3

Ref. 3D-OG03917

Product Information

• Name: GD1a-Ganglioside sodium
• Synonyms: GD1a-Ganglioside
• Brand: Biosynth
• Description: GD1a (shown as sodium salt) is one of the major gangliosides in neuronal and glial membranes. It has a core tetrasaccharide structure (Galβ1,3GalNAcβ1,4Galβ1,4Glc) with sialic acids linked α2,3/α2,8 to the inner galactose residue, α2,3 to the outer galactose residue and ceramide linked β to position 1 on the reducing terminal glucose residue (Ledeen, 2009). It interacts with myelin-associated glycoprotein (MAG) and is essential for long-term axon-myelin stability. It plays a role in viral infection as it is a receptor for viral glycoproteins in rotavirus and paramyxovirus 1. The hexasaccharide GD1a moiety was also found on a glycoprotein that acts as a receptor for adenovirus type 37. GD1a ganglioside also interacts with botulinum neurotoxin and is crucial for its entry into cells (Kolter, 2012).

Chemical properties

• Molecular weight: 1,838.08 g/mol
• Formula: C₈₄H₁₄₈N₄O₃₉·xNa
• Purity: Min. 95%
• Color/Form: White Powder