Product Information
Name:Ganglioside GM1
Synonyms:
- Gal(b1-3)GalNAc(b1-4)[Neu5Ac(a2-3)]Gal(b1-4)Glc(b1-1)CersMonosialogangl ioside GM1prototype gangliosidemonosialotetrahexosylganglioside Ganglioside Monosialotetrahexosylganglioside
Brand:Biosynth
Description:Ganglioside GM1 has a core tetrasaccharide structure (Galβ1,3GalNAcβ1,4Galβ1,4Glc) with sialic acid linked α2,3 to the inner galactose residue, ceramide linked β to position 1 on the reducing terminal glucose residue (Ledeen, 2009), and is abundant in all mammalian brains, where it covers 10%-20% of the total ganglioside mixture. Ganglioside GM1 is found in epithelial membranes and is a key element for the detection of bacterial toxicity and viral infection. It is the intestinal receptor for cholera toxin, the B-subunits of heat-labile toxin (LTB) from E.coli, for rotavirus, and simian virus 40. GM1 functions as a neurotrophic and neuroprotective compound and has been used therapeutically for diabetic and peripheral neuropathies. It also has the ability to bind amyloid-β proteins and is involved in Alzheimer’s pathogenesis (Chiricozzi, 2020).
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:1,546.82 g/mol
Formula:C73H131N3O31·xNa
Purity:Min. 95 Area-%
Color/Form:White Powder
Technical inquiry about: Ganglioside GM1
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