GD3-Ganglioside sodium

CAS: 62010-37-1

Ref. 3D-OG03922

Product Information

• Name: GD3-Ganglioside sodium
• Synonyms: Disialosyllactosylceramide, G(D3) Ganglioside, G_D3, GD3, GD3 Ganglioside, Ganglioside D3, Ganglioside D₃, Ganglioside G_D3, Ganglioside, GD3, Gd(3), N-Acetylneuraminyl N-acetylneuraminylgalactosylglucosylceramide

Description

GD3 (shown as sodium salt) has a core disaccharide structure (Galβ1,4Glc) with two sialic acids linked α2,3/α2,8 to the non-reducing galactose residue and ceramide linked β to position 1 on the reducing terminal glucose residue (Ledeen, 2009). GD3 is a minor ganglioside in most normal tissues but plays a crucial role in the development of the brain; it is significantly reduced in adults. However, expression of GD3 is increased in pathological conditions, such as, cancers and neurodegenerative disorders (Malisan, 2002). GD3 was the first cancer-associated ganglioside discovered that promotes adhesion and invasion of cancers. GD3 and GD2 are highly expressed in a various malignant tumours and have become potential targets for next-generation cancer therapy (Liu, 2018).

• Brand: Biosynth

Chemical properties

• Molecular weight: 1,472.74 g/mol
• Formula: C₇₀H₁₂₅N₃O₂₉·xNa
• Purity: One Spot
• Color/Form: White/Off-White Solid