GM3-Ganglioside labelled by NBD ammonium
Ref. 3D-OG09793
| 1mg | To inquire | ||
| 100µg | To inquire | ||
| 200µg | To inquire | ||
| 500µg | To inquire |
Product Information
- N-Acetyl-a-D-neuraminic acid)-(2->3)-O-b-D-galactopyranosyl-(1->4)-O-b-D-glucopyranosyl-(1->1)-(2S,3R,4E)-2-N-(7-nitrobenz-2-oxa-1,3 -diazol-4-yl)aminooctanamido-4-octadecene-1,3-diol ammonium saltaNeu5Ac(2-3)bDGalp(1-4)bDGlcp(1-1)Cer linked 7-n
GM3-ganglioside NBD (ammonium salt) has a core disaccharide structure (Galβ1,4Glc) with sialic acid linked α2,3 to the galactose residue with nitrobenzoxadiazole (NBD) linked β to position 1 on the reducing terminal glucose residue, in place of the ceramide fatty acid (Ledeen, 2009). Ganglioside GM3 is strongly associated with human tumors, such as, lung, brain, and melanomas, where it is frequently found to be overexpressed. GM3 ganglioside is seen as a possible tumor-associated carbohydrate antigen for cancer immunotherapy (Changping, 2019). GM3 ganglioside is implicated in various other diseases involving chronic inflammation, such as: insulin resistance, leptin resistance, T-cell function, and immune disorders (e.g. allergic asthma). It has also been shown to play an essential role in murine and human auditory systems, and is a common pathological feature of GM3S deficiency is deafness (Inokuchi, 2018).
Chemical properties
Technical inquiry about: 3D-OG09793 GM3-Ganglioside labelled by NBD ammonium
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