Product Information
Name:GM2-Ganglioside
Synonyms:
- Monosialoganglioside GM2
Brand:Biosynth
Description:GM2 ganglioside (sodium salt) has a core trisaccharide structure (GalNAcβ1,4Galβ1,4Glc) with sialic acid linked α2,3 to the central galactose residue and ceramide linked β to position 1 on the reducing terminal glucose residue (Ledeen, 2009). GM2 ganglioside is present on neuronal cells and plays a key role in the regulation of dendritogenesis in cortical pyramidal neurons. In lysosomal storage disorders, such as, Tay-Sachs and Sandhoff disease, where hexosaminases A and B are deficient, GM2 ganglioside accumulates in the nervous system (Cachon-Gonzalez, 2018). GM2 ganglioside is also overexpressed in melanomas and other tumours of neuro-ecto origin (Yoshida, 2020). Moreover, the sugar moiety of the GM2 ganglioside is a receptor allowing the viral infection of cells with reovirus and rotavirus (Zhu, 2018).
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Chemical properties
Purity:Min. 96%
Color/Form:Powder
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