GQ1b-Ganglioside sodium

CAS: 68652-37-9

Ref. 3D-OG16190

Product Information

• Name: GQ1b-Ganglioside sodium
• Synonyms: Tetrasialoganglioside 1b
• Brand: Biosynth
• Description: GQ1b ganglioside (sodium salt) has a core tetrasaccharide structure (Galβ1,3GalNAcβ1,4Galβ1,4Glc) with two sialic acids (NeuAc) linked α2,3/α2,8 to the inner galactose residue, two sialic acids (NeuAc) linked α2,3/α2,8 to the terminal galactose residue and ceramide linked β to position 1 on the reducing terminal glucose residue (Ledeen, 2009). Anti-GQ1b ganglioside antibody is associated with Miller Fisher syndrome and is also found in patients with related conditions that may share the same pathogenic mechanism, such as, Bickerstaff brainstem encephalitis. Thus, the measurement of the anti-GQ1b antibody in suspected cases of Miller Fisher syndrome is a useful diagnostic marker (Paparounas, 2004). It has been found that GQ1b ganglioside contributes to synaptic transmission and synapse formation. Low concentrations of GQ1b ganglioside, evoked dopamine (DA) release from laboratory tissues (Chen, 2018).

Chemical properties

• Molecular weight: 2,528.55 g/mol
• Formula: C₁₀₆H₁₈₂N₆O₅₆·4Na
• Purity: Min. 95%
• Color/Form: White Powder