GT1b-Ganglioside ammonium

CAS: 59247-13-1

Ref. 3D-OG167138

Product Information

• Name: GT1b-Ganglioside ammonium
• Brand: Biosynth
• Description: GT1b ganglioside (ammonium salt) has a core tetrasaccharide structure (Galβ1,3GalNAcβ1,4Galβ1,4Glc) with two sialic acids (NeuAc) linked α2,3/α2,8 to the inner galactose residue, sialic acid (NeuAc) linked α2,3 to the terminal galactose residue, and ceramide linked β to position 1 on the reducing terminal glucose residue (Ledeen, 2009). GT1b ganglioside is one of the major gangliosides in neuronal and glial membranes. It interacts with myelin-associated glycoprotein (MAG) and is essential for long-term axon-myelin stability. GT1b ganglioside also acts as a receptor for bacterial toxins, such as, tetanus and botulinum toxins (Nishiki, 1996), as well as for viruses. A few examples of which include: Merkel cell polyomavirus, JC virus, BK virus, norovirus, and others (Low, 2006).

Chemical properties

• Molecular weight: 2,145.33 g/mol
• Formula: C₉₅H₁₆₅N₅O₄₈·xNH₄
• Purity: Min. 95%
• Color/Form: Powder