GM1-Ganglioside labelled by biotin

Ref. 3D-OG31354

Product Information

• Name: GM1-Ganglioside labelled by biotin
• Synonyms: N-Hexanoyl-biotin-monosialoganglioside GM1
• Brand: Biosynth
• Description: GM1-biotin ganglioside (sodium salt) has a core tetrasaccharide structure (Galβ1,3GalNAcβ1,4Galβ1,4Glc) with sialic acid linked α2,3 to the inner galactose residue, ceramide linked β to position 1 on the reducing terminal glucose residue, and biotin to position 5 on sialic acid (Ledeen, 2009). GM1 ganglioside is abundant in all mammalian brains where it covers 10%-20% of the total ganglioside mixture. It is found in epithelial membranes and is a key element for bacterial toxicity and viral infection as it is the intestinal receptor for the cholera toxin, the B-subunits of heat-labile toxin, rotavirus, and simian virus 40. GM1 ganglioside functions as a neurotrophic and neuroprotective compound, and has been used therapeutically for diabetic and peripheral neuropathies. GM1 ganglioside also has the ability to bind amyloid-β proteins and is involved in Alzheimer’s pathogenesis (Chiricozzi, 2020).

Chemical properties

• Molecular weight: 1,619.82 g/mol
• Formula: C₇₁H₁₂₂N₆O₃₃S
• Purity: Min. 95%