Gracillin

CAS: 19083-00-2

Ref. 3D-OG59524

Product Information

• Name: Gracillin
• Synonyms: (3beta,25R)-spirost-5-en-3-yl 6-deoxy-alpha-L-mannopyranosyl-(1->2)-[beta-D-glucopyranosyl-(1->3)]-beta-D-glucopyranoside, (3β,25R)-Spirost-5-en-3-yl O-6-deoxy-α-<span class="text-smallcaps">L</smallcap>-mannopyranosyl-(1→2)-O-[β-<smallcap>D</smallcap>-glucopyranosyl-(1→3)]-β-<smallcap>D</span>-glucopyranoside, 25(R)-Diosgenin 3-O-β-<span class="text-smallcaps">D</smallcap>-glucopyranosyl-(1→3)-[α-<smallcap>L</smallcap>-rhamnopyranosyl-(1→2)]-β-<smallcap>D</span>-glucopyranoside, Ccris 4124, Diosgenin 3-O-(α-<span class="text-smallcaps">L</smallcap>-rhamnopyranosyl(1→2)-[β-<smallcap>D</smallcap>-glucopyranosyl(1→3)])-β-<smallcap>D</span>-glucopyranoside, Diosgenin 3-O-β-gracillimatrioside, Dulcamarin C, Gracilline, Lilioglycoside G, Nsc 698787, Spirost-5-En-3-Yl 6-Deoxyhexopyranosyl-(1->2)-[Hexopyranosyl-(1->3)]Hexopyranoside, beta-D-Glucopyranoside, (3beta,25R)-spirost-5-en-3-yl O-6-deoxy-alpha-L-mannopyranosyl-(1-2)-O-(beta-D-glucopyranosyl-(1-3))-, β-<span class="text-smallcaps">D</smallcap>-Glucopyranoside, (3β,25R)-spirost-5-en-3-yl O-6-deoxy-α-<smallcap>L</smallcap>-mannopyranosyl-(1→2)-O-[β-<smallcap>D</span>-glucopyranosyl-(1→3)]-

Description

Gracillin is a natural compound that is isolated from the roots of Cimicifuga foetida. It has been shown to have an anti-inflammatory effect and can be used as a potential anticancer agent. Gracillin inhibits the activities of matrix metalloproteinase (MMP) and proteinase 3 (PR3), which are enzymes that break down collagen in the extracellular matrix, leading to cancer cell proliferation. Gracillin also binds to response elements on genes and alters gene transcription. The effects of gracillin on inflammation may be due to its ability to inhibit enzyme activities such as cyclooxygenase, lipoxygenase, and phospholipase A2, which are involved in inflammatory reactions. Gracillin has been shown to cause acute toxicities including death in rats at high doses, but no signs of toxicity were observed for lower doses.

• Brand: Biosynth

Chemical properties

• Molecular weight: 885.04 g/mol
• Formula: C₄₅H₇₂O₁₇
• Purity: Min. 95%
• Color/Form: White Powder