Product Information
- Lipid A 406
- LA-14-PP
- Precursur 1a
- Lipid IVa triethylammonium
Lipid IVA is a tetra-acylated precursor molecule of lipid A which is a component of lipopolysaccharides (LPS) on the outer membrane of gram-negative bacteria. On the innate immune cells of hosts there are toll-like receptor 4 (TLR4) and MD-2 which recognize LPS. This recognition event ultimately leads to the activation of NFκB which in turn results in pro-inflammatory cytokine production. Studies have suggested lipid A in Escherichia coli to be an agonist for both mouse and human TLR4, while lipid IVA can induce species specific TLR4 responses. For example for horse and mouse TLR4 and MD-2, Lipid IVA is an agonist where as it is an antagonist for TLR4 and MD-2 in humans.
Chemical properties
Technical inquiry about: 3D-OL09566 Lipid IVa
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