GD2-Oligosaccharide

Ref. 3D-OO46222

Product Information

• Name: GD2-Oligosaccharide
• Brand: Biosynth
• Description: GD2 oligosaccharide is the core trisaccharide structure of the ganglioside GD2 (sodium salt) (GalNAcβ1,4Galβ1,4Glc) with its two sialic acids linked α2,3/α2,8 to the central galactose residue (Ledeen, 2009). GD2 ganglioside is expressed at a low concentration in the central nervous system, nerves, skin melanocytes and stem cells in healthy adults. On the other hand, GD2 ganglioside is overexpressed in a number of tumors, including: neuroblastoma, melanoma, small cell lung carcinoma and brain tumors. Recently, GD2 ganglioside has been found in low concentrations on breast cancer stem cells (CSC) that possess: self-renewal properties (division without disrupting the undifferentiated state) and tumor-initiating capabilities. It has been suggested that GD2 ganglioside may be developed as an effective target antigen for CSC immunotherapy (Fleurence, 2017).

Chemical properties

• Molecular weight: 1,171.96 g/mol
• Formula: C₄₂H₆₇N₃O₃₂Na₂
• Purity: Min. 95%
• Color/Form: White Powder