GM2-Oligosaccharide
Ref. 3D-OO46228
| 1mg | 395.00 € | ||
| 2mg | 547.00 € | ||
| 5mg | 1,094.00 € | ||
| 10mg | 1,925.00 € | ||
| 25mg | 4,155.00 € |
Product Information
GM2-oligosaccharide (sodium salt) is a trisaccharide (GalNAcβ1,4Galβ1,4Glc) with sialic acid linked α2,3 to the central galactose residue (Ledeen, 2009). The parent GM2 ganglioside is present on neuronal cells and plays a key role in the regulation of dendritogenesis in cortical pyramidal neurons. In lysosomal storage disorders, such as, Tay-Sachs and Sandhoff disease, where hexosaminases A and B are deficient, GM2 ganglioside accumulates in the nervous system (Cachon-Gonzalez, 2018). GM2 ganglioside is also overexpressed in melanomas and other tumours of neuro-ecto origin (Yoshida, 2020). Moreover, the sugar moiety of GM2 ganglioside is a receptor allowing viral infection of cells with reovirus and rotavirus (Zhu, 2018).
Chemical properties
Technical inquiry about: 3D-OO46228 GM2-Oligosaccharide
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