GM2-Oligosaccharide

Ref. 3D-OO46228

Product Information

• Name: GM2-Oligosaccharide
• Brand: Biosynth
• Description: GM2-oligosaccharide (sodium salt) is a trisaccharide (GalNAcβ1,4Galβ1,4Glc) with sialic acid linked α2,3 to the central galactose residue (Ledeen, 2009). The parent GM2 ganglioside is present on neuronal cells and plays a key role in the regulation of dendritogenesis in cortical pyramidal neurons. In lysosomal storage disorders, such as, Tay-Sachs and Sandhoff disease, where hexosaminases A and B are deficient, GM2 ganglioside accumulates in the nervous system (Cachon-Gonzalez, 2018). GM2 ganglioside is also overexpressed in melanomas and other tumours of neuro-ecto origin (Yoshida, 2020). Moreover, the sugar moiety of GM2 ganglioside is a receptor allowing viral infection of cells with reovirus and rotavirus (Zhu, 2018).

Chemical properties

• Molecular weight: 858.73 g/mol
• Formula: C₃₁H₅₁N₂O₂₄Na
• Purity: Min. 95%
• Color/Form: Powder