GM1a-Oligosaccharide

Ref. 3D-OO46231

Product Information

• Name: GM1a-Oligosaccharide
• Synonyms: Galb1-3GalNAcb1-4(Neu5Aca2-3)Galb1-4Glc
• Brand: Biosynth
• Description: GM1a pentasaccharide (ammonium salt) has a core tetrasaccharide structure (Galβ1,3GalNAcβ1,4Galβ1,4Glc) with a single sialic acid residue linked α2,3 to the inner galactose residue (Ledeen, 2009). GM1a pentasaccharide is the carbohydrate moiety in GM1a ganglioside which interacts and modulates tyrosine kinases, such as, neural tropomyosin receptor kinase A (TrkA), by inducing the release of neurotrophins from fibroblast cells and the epidermal growth factor receptor (EGFR) (Higuero, 2009). Oligosaccharide domain of monosialylated glycosphingolipid GM1 of a-series that specifically interacts with cholera toxin B subunit (CBT) from V. cholerae, heat-labile toxin B subunit (LTB) from E. coli and alpha toxin from C. perfrigens. This ganglioside is abundant in nervous system as well as in other peripheral tissues (Chiricozzi, 2020).

Chemical properties

• Molecular weight: 1,020.87 g/mol
• Formula: C₃₇H₆₁N₂O₂₉Na
• Purity: Min. 95%
• Color/Form: Powder