GD2-Oligosaccharide-sp-biotin

Ref. 3D-OO71835

Product Information

• Name: GD2-Oligosaccharide-sp-biotin
• Brand: Biosynth
• Description: The structure of GD2-oligosaccharide-sp-biotin (sodium salt) comprises (GalNAcβ1,4Galβ1,4Glc) with two sialic acids linked (β-2,3/β-2,8) to the central galactose residue and biotin attached to position 1 of the reducing glucose moiety. GD2 ganglioside is expressed at a low concentration in the central nervous system, nerves, skin melanocytes and stem cells in healthy adults. On the other hand, GD2 ganglioside is overexpressed in a number of tumors, including: neuroblastoma, melanoma, small cell lung carcinoma and brain tumors. Recently, it has been found in low concentrations on breast cancer stem cells (CSC) that possess: self-renewal properties (division without disrupting the undifferentiated state) and tumor-initiating capabilities. It has been suggested that GD2 ganglioside may be developed as an effective target antigen for CSC immunotherapy.

Chemical properties

• Molecular weight: 1,695.61 g/mol
• Formula: C₆₅H₁₀₄N₁₀O₃₇S·2Na
• Purity: One Spot
• Color/Form: White Powder