GD2-Oligosaccharide-sp-biotin
Ref. 3D-OO71835
| 1mg | 5,490.00 € | ||
| 50µg | 745.00 € | ||
| 100µg | 1,114.00 € | ||
| 200µg | 1,713.00 € | ||
| 500µg | 3,294.00 € |
Product Information
The structure of GD2-oligosaccharide-sp-biotin (sodium salt) comprises (GalNAcβ1,4Galβ1,4Glc) with two sialic acids linked (β-2,3/β-2,8) to the central galactose residue and biotin attached to position 1 of the reducing glucose moiety. GD2 ganglioside is expressed at a low concentration in the central nervous system, nerves, skin melanocytes and stem cells in healthy adults. On the other hand, GD2 ganglioside is overexpressed in a number of tumors, including: neuroblastoma, melanoma, small cell lung carcinoma and brain tumors. Recently, it has been found in low concentrations on breast cancer stem cells (CSC) that possess: self-renewal properties (division without disrupting the undifferentiated state) and tumor-initiating capabilities. It has been suggested that GD2 ganglioside may be developed as an effective target antigen for CSC immunotherapy.
Chemical properties
Technical inquiry about: 3D-OO71835 GD2-Oligosaccharide-sp-biotin
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