GD2-Oligosaccharide-b-(N-acetyl-propargyl)

Ref. 3D-OO76149

Product Information

• Name: GD2-Oligosaccharide-b-(N-acetyl-propargyl)
• Synonyms: GD2-Saccharide-b-NAc-propargyl
• Brand: Biosynth
• Description: The core trisaccharide of the ganglioside GD2,protected with a propargyl glycoside group, is the most prominent alkynyl glycoside used in oligosaccharide synthesis (Das, 2016). The structure (sodium salt) comprises (GalNAcβ1,4Galβ1,4Glc) of its two sialic acids linked α2,3/α2,8 to the central galactose residue (Ledeen, 2009). GD2 ganglioside is expressed at a low concentration in the central nervous system, nerves, skin melanocytes and stem cells in healthy adults. On the other hand, GD2 ganglioside is overexpressed in a number of tumors including neuroblastoma, melanoma, small cell lung carcinoma and brain tumors. Recently, GD2 ganglioside has been found in low concentrations on breast cancer stem cells (CSC) that possess: self-renewal properties (division without disrupting the undifferentiated state) and tumor-initiating capabilities. It has been suggested that GD2 ganglioside may be developed as an effective target antigen for CSC immunotherapy (Fleurence, 2017).

Chemical properties

• Molecular weight: 1,251.06 g/mol
• Formula: C₄₇H₇₂N₄O₃₂Na₂
• Purity: Min. 95%