GM1-Pentasaccharide labelled by biotin

Ref. 3D-OP31185

Product Information

• Name: GM1-Pentasaccharide labelled by biotin
• Synonyms: GM1-Pentasaccharide-O(CH2)3NHCO(CH2)5NH-biotin
• Brand: Biosynth
• Description: GM1 pentasaccharide biotin (sodium salt) has a core tetrasaccharide structure (Galβ1,3GalNAcβ1,4Galβ1,4Glc) with sialic acid linked α2,3 to the inner galactose residue and biotin linked β to position 1 on the reducing glucose moiety (Ledeen, 2009). The parent ganglioside GM1 is abundant in all mammalian brains, where it covers 10%-20% of the total ganglioside mixture. It is found in epithelial membranes and is a key element for bacterial toxicity and viral infection as it is the intestinal receptor for cholera toxin the B-subunits of heat-labile toxin, rotavirus, and simian virus 40. GM1 ganglioside functions as a neurotrophic and neuroprotective compound and has been used therapeutically for diabetic and peripheral neuropathies. GM1 ganglioside also has the ability to bind amyloid-β proteins and is involved in Alzheimer’s pathogenesis (Chiricozzi, 2020).

Chemical properties

• Molecular weight: 1,282.28 g/mol
• Formula: C₅₀H₈₃N₅O₃₁S
• Purity: Min. 95%
• Color/Form: White Powder