3'-Sialyl Lewis X, sodium salt

CAS: 98603-84-0

Ref. 3D-OS04058

Product Information

• Name: 3'-Sialyl Lewis X, sodium salt
• Synonyms: NeuNAc-a2-3Gal-b1-4(Fuc-a1-3)GlcNAc, 3′-Sialyl-Lewis X, 5-(acetylamino)-3,5-dideoxy-D-erythro-non-2-ulopyranonosyl-(2->3)hexopyranosyl-(1->4)-[6-deoxyhexopyranosyl-(1->3)]-2-(acetylamino)-2-deoxyhexopyranose, 5-(acetylamino)-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranonosyl-(2->3)-beta-D-galactopyranosyl-(1->4)-[6-deoxy-alpha-L-galactopyranosyl-(1->3)]-2-(acetylamino)-2-deoxy-D-glucose, <span class="text-smallcaps">D</smallcap>-Glucose, O-(N-acetyl-α-neuraminosyl)-(2→3)-O-β-<smallcap>D</smallcap>-galactopyranosyl-(1→4)-O-[6-deoxy-α-<smallcap>L</span>-galactopyranosyl-(1→3)]-2-(acetylamino)-2-deoxy-, O-(N-Acetyl-α-neuraminosyl)-(2→3)-O-β-<span class="text-smallcaps">D</smallcap>-galactopyranosyl-(1→4)-O-[6-deoxy-α-<smallcap>L</smallcap>-galactopyranosyl-(1→3)]-2-(acetylamino)-2-deoxy-<smallcap>D</span>-glucose, SLe^x, Sialyl Le^x tri, Sialyl Lewis X, Ssea 1, SLex, D-Glucose, O-(N-acetyl-α-neuraminosyl)-(2→3)-O-β-D-galactopyranosyl-(1→4)-O-[6-deoxy-α-L-galactopyranosyl-(1→3)]-2-(acetylamino)-2-deoxy-, O-(N-Acetyl-α-neuraminosyl)-(2→3)-O-β-D-galactopyranosyl-(1→4)-O-[6-deoxy-α-L-galactopyranosyl-(1→3)]-2-(acetylamino)-2-deoxy-D-glucose

Description

Sialyl Lewis X (SLeX) is a carbohydrate antigen, related to cell adhesion and it has been shown that inhibition of SLeX synthesis leads to decreased adhesion of trophoblast cells to endometrial epithelial cells (Collins, 2006). Sialyl Lewis X is displayed on the terminus of glycolipids that are present on the surface of white blood cells and it has been shown that SLeX has an important role in inflamation processes. The inital adhesion of white blood cells to a site of injury is mediated by E-selectins which are specific for SLeX. Cell-cell recognition between leukocytes and endothelial cells in blood is believed to occur in part through interactions between lectins and oligosaccharide ligands. SLeX is frequently expressed in human cancer cells and primary tumors. It has been demonstrated that SLeX was involved in the adhesion of tumor cells to vascular endothelium. The potential role of SLeX in the tumor metastatic process has been supported by several clinical studies (Liang, 2016).

• Brand: Biosynth

Chemical properties

• Molecular weight: 842.73 g/mol
• Formula: C₃₁H₅₁N₂NaO₂₃
• Purity: Min. 95%
• Color/Form: White Powder