Timosaponin A-III
CAS: 41059-79-4
Ref. 3D-OT10477
| 2mg | 136.00 € | ||
| 5mg | 206.00 € | ||
| 10mg | 346.00 € | ||
| 25mg | 452.00 € | ||
| 50mg | 723.00 € |
Product Information
- Anemarsaponin A3Filiferin B(3b,5b,25S)-Spirostan-3-yl 2-O-b-D-glucopyranosyl-b-D-galactopyranoside
- Timosaponine A III
- Timosaponin A III
- (3β,5β,25S)-Spirostan-3-yl 2-O-β-D-glucopyranosyl-β-D-galactopyranoside
- β-D-Galactopyranoside, (3β,5β,25S)-spirostan-3-yl 2-O-β-D-glucopyranosyl-
- Filiferin B
Timosaponin A-III is a saponin compound that is found in the roots of Timosaponis chinensis. It has been shown to have anti-cancer effects in vitro, as well as anti-inflammatory and antioxidant properties. In particular, it inhibits the function of P-glycoprotein (Pgp) and prevents its translocation from the Golgi apparatus to the cell membrane. This decreases the efflux of anticancer drugs from cells. Timosaponin A-III also has an effect on cyclin D2, which is a protein that regulates cell cycle progression. The hypoglycemic effect seen in animal studies may be due to its synergic effect with insulin and preparative high performance liquid chromatography (HPLC). Timosaponin A-III also has significant cytotoxicity against HL-60 cells, which are a type of leukemia cells. It binds to response elements on DNA and activates transcription factors such as NF-κB and AP1,
Chemical properties
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