1-(6-Chloropyridazin-3-yl)-3-methyl-4,5-dihydro-1H-pyrazol-5-one
CAS: 14246-87-8
Ref. 3D-PAA24687
| 50mg | 185.00 € | ||
| 500mg | 733.00 € |
Product Information
1-(6-Chloropyridazin-3-yl)-3-methyl-4,5-dihydro-1H-pyrazol-5-one (1) was found to be a potent inhibitor of β amyloid fibril formation and a lead compound for the treatment of Alzheimer's disease. The compound inhibits amyloid fibril formation by binding to the hydrophobic region in the core of the fibrils and preventing crosslinking. 1 also inhibits pancreatic β cell secretion, resulting in reduced production of insulin, which causes glucose intolerance. This drug has been shown to reduce glycemic levels in diabetic mice without causing hypoglycemia.
Chemical properties
Technical inquiry about: 3D-PAA24687 1-(6-Chloropyridazin-3-yl)-3-methyl-4,5-dihydro-1H-pyrazol-5-one
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