Product Information
- H 8325
- Fllrn
- Phe-leu-leu-arg-asn
- Phenylalanyl-leucyl-leucyl-arginyl-asparagine
- L-Asparagine, N2-(N2-(N-(N-L-phenylalanyl-L-leucyl)-L-leucyl)-L-arginyl)-
H-Phe-Leu-Leu-Arg-Asn-OH is a β-amino acid that has been shown to have antioxidant properties. It acts as a competitive inhibitor of the enzyme collagenase and has been shown to inhibit the development of atherosclerotic lesions in mice. The amide form of H-Phe-Leu-Leu-Arg-Asn has also been shown to have site specific activity on ventricular myocardium cells, which may be related to its ability to induce cytosolic calcium release. HPLR also has protease activity that can be inhibited by urea nitrogen and β amino acid. Basophilic leukemia cells produce HPLR at high levels and it is thought that this is due to an increased requirement for the production of collagen in these cells.
HPLR has been shown to activate thrombin receptors, which are found on the surface of platelets and endothelial cells. Activated thrombin
Chemical properties
Technical inquiry about: 3D-PAR-3944-PI H-Phe-Leu-Leu-Arg-Asn-OH
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