N6-Benzoyl-5'-O-DMT-2'-O-methyladenosine 3'-CE phosphoramidite

CAS: 110782-31-5

Ref. 3D-PB08471

Product Information

• Name: N6-Benzoyl-5'-O-DMT-2'-O-methyladenosine 3'-CE phosphoramidite
• Synonyms: N6-Benzoyl-5'-O-DMT-2'-O-methyl-D-adenosine 3'-CE phosphoramidite
• Brand: Biosynth
• Description: N6-Benzoyl-5'-O-DMT-2'-O-methyladenosine 3'-CE phosphoramidite is a nucleoside phosphoramidite used as a building block in the chemical synthesis of oligonucleotides containing a 2’-O-methyl adenosine nucleoside unit. The use of a chemical synthesis rather than an enzymatic one allows oligonucleotides of a desired sequence to be produced. 3’-Cyanoethyl phosphoramidites are typically used by substitution of the di-isopropylamine group with an appropriate alcohol in the presence of an azole catalyst. Oligonucleotides containing 2'-O-methylribonucleoside units have shown site-specific cleavage with E. coli RNase H, either at a hairpin loop or at a stem region.

Chemical properties

• Molecular weight: 887.98 g/mol
• Formula: C₄₈H₅₄N₇O₈P
• Purity: Min. 98 Area-%
• Color/Form: White Off-White Powder