N4-Benzoyl-2'-deoxy-5'-O-DMT-5-methylcytidine 3'-CE phosphoramidite

CAS: 105931-57-5

Ref. 3D-PB09089

Product Information

• Name: N4-Benzoyl-2'-deoxy-5'-O-DMT-5-methylcytidine 3'-CE phosphoramidite
• Synonyms: N4-Bz-5'-DMT-5-Me-dC phosphoramiditeN4-Benzoyl-2'-Deoxy-5'-O-DMT-5-methyl-D-cytidine 3'-CE phosphoramiditeN4-Benzoyl-5'-O-DMT-5-me thyl-2'-Deoxycytidine 3'-CE phosphoramidite, 4: PN: US20030212017 PAGE: 17 claimed DNA, 5'-O-(4,4'-Dimethoxytrityl)-5-Methyl-N4-Benzoyl-2'-Deoxycytidine-3'-(2-Cyanoethyl-N,N-Diisopropyl)Phosphoramidite, 5: PN: US20030211606 PAGE: 17 claimed DNA, 6: PN: US20040014048 PAGE: 18 claimed DNA, 6: PN: US20040014049 PAGE: 18 claimed DNA, 7: PN: US20030198965 PAGE: 17 claimed DNA, 7: PN: US20040014047 PAGE: 18 claimed DNA, 80: PN: US20040005707 PAGE: 18 claimed DNA, 8: PN: US20040005565 PAGE: 17-22 claimed DNA, 8: PN: US20040005569 PAGE: 20 claimed DNA, 8: PN: US20040005570 PAGE: 18 claimed DNA, 8: PN: US20040006029 PAGE: 20 claimed DNA, 8: PN: US20040006030 PAGE: 20 claimed DNA, 8: PN: US20040014050 PAGE: 18 claimed DNA, 8: PN: US20040014051 PAGE: 20 claimed DNA, 8: PN: US20040014699 PAGE: 18 claimed DNA, 8: PN: WO03106645 PAGE: 64 claimed DNA, Cytidine, N-benzoyl-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-deoxy-5-methyl-, 3′-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite], Cytidine, N-benzoyl-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-deoxy-5-methyl-, 3′-[2-cyanoethyl bis(1-methylethyl)phosphoramidite], N4-Benzoyl-5-Methyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine-3'-cyanoethyl Phosphoramidite

Description

Nucleoside phosphoramidites are widely used as building blocks in the chemical synthesis of oligonucleotides. The use of a chemical synthesis rather than an enzymatic one allows bespoke oligonucleotides of a desired sequence to be obtained. 3’-Cyanoethyl phosphoramidites are typically modified by reaction with the 5’ hydroxyl of the next nucleoside in the desired sequence. The reaction is usually catalysed by 1H-tetrazole or 4,5-dicyanoimidazole in acetonitrile. N4-Benzoyl-2'-deoxy-5'-O-DMT-5-methylcytidine 3'-CE phosphoramidite, also called N4-Bz-5'-DMT-5-Me-dC phosphoramidite, is used in the synthesis of 2’-deoxy-5-methylcytidine-containing oligonucleotides as antisense drugs.

• Brand: Biosynth

Chemical properties

• Molecular weight: 847.93 g/mol
• Formula: C₄₇H₅₄N₅O₈P
• Purity: Min. 95%
• Color/Form: White Powder
• SMILES: COc1ccc(C(OC[C@H]2O[C@@H](n3cc(C)c(NC(=O)c4ccccc4)nc3=O)C[C@@H]2OP(OCCC#N)N(C(C)C)C(C)C)(c2ccccc2)c2ccc(OC)cc2)cc1