N4-Benzoyl-2'-deoxy-5'-O-DMT-5-methylcytidine 3'-CE phosphoramidite

CAS: 105931-57-5

Ref. 3D-PB09089

Product Information

• Name: N4-Benzoyl-2'-deoxy-5'-O-DMT-5-methylcytidine 3'-CE phosphoramidite
• Synonyms: N4-Bz-5'-DMT-5-Me-dC phosphoramiditeN4-Benzoyl-2'-Deoxy-5'-O-DMT-5-methyl-D-cytidine 3'-CE phosphoramiditeN4-Benzoyl-5'-O-DMT-5-me thyl-2'-Deoxycytidine 3'-CE phosphoramidite
• Brand: Biosynth
• Description: Nucleoside phosphoramidites are widely used as building blocks in the chemical synthesis of oligonucleotides. The use of a chemical synthesis rather than an enzymatic one allows bespoke oligonucleotides of a desired sequence to be obtained. 3’-Cyanoethyl phosphoramidites are typically modified by reaction with the 5’ hydroxyl of the next nucleoside in the desired sequence. The reaction is usually catalysed by 1H-tetrazole or 4,5-dicyanoimidazole in acetonitrile. N4-Benzoyl-2'-deoxy-5'-O-DMT-5-methylcytidine 3'-CE phosphoramidite, also called N4-Bz-5'-DMT-5-Me-dC phosphoramidite, is used in the synthesis of 2’-deoxy-5-methylcytidine-containing oligonucleotides as antisense drugs.

Chemical properties

• Molecular weight: 847.93 g/mol
• Formula: C₄₇H₅₄N₅O₈P
• Purity: Min. 95%
• Color/Form: White Powder
• SMILES: COc1ccc(C(OC[C@H]2O[C@@H](n3cc(C)c(NC(=O)c4ccccc4)nc3=O)C[C@@H]2OP(OCCC#N)N(C(C)C)C(C)C)(c2ccccc2)c2ccc(OC)cc2)cc1