N4-Benzoyl-5'-O-DMT-2'-O-(2-methoxyethyl)-5-methylcytidine 3'-CE phosphoramidite
CAS: 163759-94-2
Ref. 3D-PB64062
| 5g | 664.00 € | ||
| 10g | 984.00 € | ||
| 25g | 1,819.00 € |
Product Information
- 5-Me-DMT-2'-O-MOE-C(Bz)-CEP
- 5-Me-DMT-2'-O-MOE-C(Bz)-CE Phosphoramidite
- 2'-O-Methyl-N4-Benzoyl-5'-O-DMT-Cytidine-3'-CE-Phosphoramidite
- N4-Benzoyl-5-methyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-cytidine-3'-cyanoethyl Phosphoramidite
Nucleoside phosphoramidites are used in the chemical synthesis of oligonucleotides. Using a chemical approach rather than an enzymatic one allows quick and inexpensive access to custom-made oligonucleotides of the desired sequence. Differently from the enzymatic synthesis, the chemically synthesised oligonucleotide sequence is typically constructed in a 3’ to 5’ direction. N4-Benzoyl-5'-O-DMT-2'-O-(2-methoxyethyl)-5-methylcytidine 3'-CE phosphoramidite, also called 5-Me-DMT-2'-O-MOE-C(Bz)-CEP, has been used in the synthesis of oligonucleotides which are specifically hybridizable with nucleic acids encoding multidrug resistant-associated protein (MRP). The antisense oligonucleotide ISIS 13041 gave almost complete removal of resistance to vincristine, a chemotherapy drug.
Chemical properties
Technical inquiry about: 3D-PB64062 N4-Benzoyl-5'-O-DMT-2'-O-(2-methoxyethyl)-5-methylcytidine 3'-CE phosphoramidite
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