N4-Benzoyl-5'-O-DMT-2'-O-(2-methoxyethyl)-5-methylcytidine 3'-CE phosphoramidite

CAS: 163759-94-2

Ref. 3D-PB64062

Product Information

• Name: N4-Benzoyl-5'-O-DMT-2'-O-(2-methoxyethyl)-5-methylcytidine 3'-CE phosphoramidite
• Synonyms: 5-Me-DMT-2'-O-MOE-C(Bz)-CEP
• Brand: Biosynth
• Description: Nucleoside phosphoramidites are used in the chemical synthesis of oligonucleotides. Using a chemical approach rather than an enzymatic one allows quick and inexpensive access to custom-made oligonucleotides of the desired sequence. Differently from the enzymatic synthesis, the chemically synthesised oligonucleotide sequence is typically constructed in a 3’ to 5’ direction. N4-Benzoyl-5'-O-DMT-2'-O-(2-methoxyethyl)-5-methylcytidine 3'-CE phosphoramidite, also called 5-Me-DMT-2'-O-MOE-C(Bz)-CEP, has been used in the synthesis of oligonucleotides which are specifically hybridizable with nucleic acids encoding multidrug resistant-associated protein (MRP). The antisense oligonucleotide ISIS 13041 gave almost complete removal of resistance to vincristine, a chemotherapy drug.

Chemical properties

• Molecular weight: 922.01 g/mol
• Formula: C₅₀H₆₀N₅O₁₀P
• Purity: Min. 95%
• Color/Form: White Powder