Product Information
TC-N 22a is a novel, orally active metabotropic glutamate receptor ligand that has been shown to have potent and selective pharmacological effects in rat models. TC-N 22a is a synthetic, neutralized form of the endogenous neurotransmitter glutamate. It binds to the glutamate binding site on the metabotropic glutamate receptor and inhibits glutamate activation of both ionotropic (AMPA) and metabotropic (mGluR) receptors. TC-N 22a was developed by Promega Corporation as part of a series of compounds targeting the mGluR5 receptor. In animal studies, TC-N 22a inhibited dyskinesia induced by dopamine depletion in rats with chronic Parkinson's disease.
Chemical properties
Technical inquiry about: 3D-PCC14000 TC-N 22a
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