Chemotactic Peptide

CAS: 59880-97-6

Ref. 3D-PCT-4066-V

Product Information

• Name: Chemotactic Peptide
• Synonyms: 3: PN: WO2010089019 PAGE: 22 claimed protein, 4-(2-Aminoethyl)Phenol Hydrochloride (1:1), 4-Hydroxy-phenethylamine hydrochloride, <span class="text-smallcaps">L</smallcap>-Phenylalanine, N-[N-(N-formyl-<smallcap>L</smallcap>-methionyl)-<smallcap>L</span>-leucyl]-, <span class="text-smallcaps">L</smallcap>-Phenylalanine, N-formyl-<smallcap>L</smallcap>-methionyl-<smallcap>L</span>-leucyl-, For-Met-Leu-Phe-OH, Formyl-Met-Leu-Phe-OH, N-Formyl-<span class="text-smallcaps">L</smallcap>-methionyl-<smallcap>L</smallcap>-leucyl-<smallcap>L</span>-phenylalanine, N-Formyl-Met-Leu-Phe, N-Formyl-Met-Leu-Phe-OH, N-Formyl-methionyl-leucyl-phenylalanine, N-formylmethionylleucylphenylalanine, NSC 350593

Description

As a chemotactic peptide, For-Met-Leu-Phe (FMLP) has chemotactic properties, which means it can attract cells. For example it is a chemoattractant for phagocytic leukocytes and neutrophils. Neutrophils which have seven transmembrane G-protein coupled receptors are activated during the acute inflammatory response by FMLP and other chemotactic factors which bind to its surface receptors. This results in the activate of NF- κB, MAPK and PI3K pathways. In particular FMLP is known to induce Interleukin-8 (IL-8) which is responsible for both tissue damage and the pathogenesis of inflammatory processes resulting from neutrophils. Chemotactic peptide have been used to study the function of polymorphonuclear leukocytes and other white blood cells in inflammation. Chemotactic peptides are often used as fluorescent probes to measure intracellular metabolic responses to chemoattractant stimulation.
This product is available as a 0.5mg vial.

• Brand: Biosynth

Chemical properties

• Molecular weight: 437.55 g/mol
• Formula: C₂₁H₃₁N₃O₅S
• Purity: Min. 95%