5'-O-DMT-thymidine 3'-CE phosphoramidite

CAS: 98796-51-1

Ref. 3D-PD09152

Product Information

• Name: 5'-O-DMT-thymidine 3'-CE phosphoramidite
• Synonyms: dT-CE phosphoramidite5'-Dimethoxytrityl-2'-deoxythymidine, 3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite, 5'-Dimethoxytrityl-3'-deoxythymidine 2'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite, 5'-O-(4,4'-Dimethoxytrityl)-thymidine-3'-cyanoethyl Phosphoramidite, 5′-O-(4,4′-Dimethoxytrityl)thymidine 3′-(2-cyanoethyl-N,N-diisopropylphosphoramidite), 5′-O-(4,4′-Dimethoxytriyl)thymidine 3′-(2-cyanoethyl)-N,N-diisopropylphosphoramidite, 5′-O-DMT-thymidine 3′-CE phosphoramidite, DMT-dT phosphoramidite, DNA T Phosphoramidite, DT-CE phosphoramidite, Deoxythymidine phosphoramidite, Thymidine phosphoramidite, Thymidine, 5′-O-[bis(4-methoxyphenyl)phenylmethyl]-, 3′-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite], Thymidine, 5′-O-[bis(4-methoxyphenyl)phenylmethyl]-, 3′-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]

Description

5'-O-DMT-thymidine 3'-CE phosphoramidite is a building block for the introduction of thymidine units into oligonucleotides. 5'-O-DMT-thymidine 3'-CE phosphoramidite is utilised in a broad range of applications, including the synthesis of natural and unnatural DNA and RNA strands. Phosphoramidites are the reagent class of choice for oligonucleotide synthesis as they contain readily removable orthogonal protecting groups and can be produced at reasonable scales. The diisopropylamino leaving group is readily cleaved upon exposure to an azole catalyst allowing for a highly efficient coupling reaction with a free hydroxyl group on the growing oligonucleotide and oxidation of the subsequent phosphite triester, followed by beta-elimination of the cyanoethyl group affords the stable phosphodiester linkage.

• Brand: Biosynth

Chemical properties

• Molecular weight: 744.83 g/mol
• Formula: C₄₀H₄₉N₄O₈P
• Purity: Min. 98 Area-%
• Color/Form: Powder