2'-Deoxy-2'-fluoro-5'-O-MMT-uridine 3'-CE phosphoramidite
Ref. 3D-PD09189
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Product Information
- 2'-Deoxy-2'-fluoro-5'-O-MMT-D-uridine 3'-CE phosphoramidite2'-Fluoro-5'-O-MMT-2'-deoxyuridine 3'-CE phosphoramidite
2'-Deoxy-2'-fluoro-5'-O-MMT-uridine 3'-CE phosphoramidite (2'F-5'OMMT-U) is a novel nucleoside analog that has been synthesized as a potential antiviral and anticancer agent. This compound has shown to be effective in inhibiting DNA synthesis and inducing apoptosis of cancer cells. 2'F-5'OMMT-U binds to the viral RNA polymerase, which inhibits the transcription process by preventing the formation of viral mRNA. 2'F-5'OMMT-U also inhibits protein synthesis by binding to the 50S ribosomal subunit, which prevents assembly of the ternary complex with tRNA and mRNA.
2'F-5'OMMT-U is not active against bacterial RNA polymerases or bacterial ribosomes.
Chemical properties
Technical inquiry about: 3D-PD09189 2'-Deoxy-2'-fluoro-5'-O-MMT-uridine 3'-CE phosphoramidite
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