2'-Deoxy-5'-O-DMT-N2-isobutyryl-6-thioguanosine 3-CE phosphoramidite
CAS: 125698-85-3
Ref. 3D-PD158794
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Product Information
2'-Deoxy-5'-O-DMT-N2-isobutyryl-6-thioguanosine 3-CE phosphoramidite is an anticancer agent that is used to treat leukemia and other cancers. It also has antiviral activity, inhibiting the viral enzyme RNA polymerase. It is a novel synthetic nucleoside that has been shown to be active against HIV in vitro. 2'-Deoxy-5'-O-DMT-N2-isobutyryl-6-thioguanosine 3-CE phosphoramidite is a nucleotide analogue of guanosine and is phosphorylated by cellular enzymes to form 2'-deoxyguanosine 5' phosphate. This compound binds to DNA and inhibits replication by preventing the unwinding of DNA helixes during transcription. 2'-Deoxyguanosine 5' phosphate also blocks translation by inhibiting ribosomal protein synthesis at the initiation
Chemical properties
Technical inquiry about: 3D-PD158794 2'-Deoxy-5'-O-DMT-N2-isobutyryl-6-thioguanosine 3-CE phosphoramidite
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