Product Information
- {5-nitro-1-methyl-3-phenyl-1H-indol-2-yl}methanol
- 1H-indole-2-methanol, 1-methyl-5-nitro-3-phenyl-
ML354 is a novel serine protease inhibitor that blocks the activity of the thrombin receptor by competitive inhibition. It has been shown to inhibit protease activity in rat cardiomyocytes and human cancer cells, as well as in vitro models of inflammatory bowel disease. ML354 also inhibits the activation of wild-type mice heart following ischemia reperfusion injury. ML354's mechanism of action is believed to be due to its ability to bind irreversibly with a specific site on the active site of thrombin, preventing binding with other substrates and thus inhibiting thrombin's enzymatic activity.
Chemical properties
Technical inquiry about: 3D-PDA15960 ML354
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