α-Defensin-4 (Human)

Ref. 3D-PDF-4431-S

Product Information

• Name: α-Defensin-4 (Human)
• Synonyms: HNP-4 (Human Neutrophil Peptide-4) DEFA4 alpha-Defensin-4 Val-Cys-Ser-Cys-Arg-Leu-Val-Phe-Cys-Arg-Arg-Thr-Glu-Leu-Arg-Val-Gly-Asn VCSCRLVFCRRTELRVGNCLIGGVSFTYCCTRV
• Brand: Biosynth
• Description: Antimicrobial peptide consisting of disulfide bonds between Cys2-Cys30, Cys4-Cys19, and Cys9-Cys29. Alpha-defensin-4 is a small, cationic peptide that is part of the alpha-defensin family of antimicrobial peptides in humans. It is primarily produced by neutrophils, which are a type of white blood cell that plays a critical role in the immune response to bacterial infections.Alpha-defensin-4 is known to have broad-spectrum antimicrobial activity against a wide range of bacterial pathogens, including both Gram-positive and Gram-negative bacteria. Like other alpha-defensins, alpha-defensin-4 achieves its antimicrobial activity by disrupting the cell membranes of the pathogens, leading to cell lysis and death.In addition to its antimicrobial activity, alpha-defensin-4 has been found to have other functions in the body, including modulating the immune response and promoting tissue repair. It has also been implicated in the pathogenesis of certain inflammatory and autoimmune diseases, including rheumatoid arthritis and psoriasis.Alpha-defensin-4 is typically found in various bodily fluids, including blood, urine, and semen, and its levels can be used as a diagnostic marker for certain conditions. For example, elevated levels of alpha-defensin-4 in joint fluid can be indicative of a bacterial infection in the joint, which can help to guide treatment decisions.

Chemical properties

• Molecular weight: 3,709.4 g/mol
• Formula: C₁₅₇H₂₅₅N₄₉O₄₃S₆
• Purity: Min. 95%