Dermcidin- 1L, human

Ref. 3D-PDL-4454-S

Product Information

• Name: Dermcidin- 1L, human
• Synonyms: Ser-Ser-Leu-Leu-Glu-Lys-Gly-Leu-Asp-Gly-Ala-Lys-Lys-Ala-Val-Gly-Gly-Leu-Gly-Lys-Leu-Gly-Lys-Asp-Ala-Val-Glu-Asp-Leu-Glu-Ser-Val-Gly- Lys-Gly-Ala-Val-His-Asp-Val-Lys-Asp-Val-Leu-Asp-Ser-Val-Leu
• Brand: Biosynth
• Description: Dermcidin-1L is a protein that belongs to the family of ion channels. It is a ligand for the receptor DCC. Dermcidin-1L has been shown to activate the receptor and induce chemotaxis in human neutrophils, which is mediated via activation of phospholipase C and elevation of intracellular calcium levels. This peptide also binds to the receptor LRP6 and inhibits Wnt signaling by competitively binding with LRP6-ligand complexes. Dermcidin-1L has been shown to inhibit proliferation of various cell lines, including pancreatic cancer cells, breast cancer cells, and leukemia cells.

Chemical properties

• Molecular weight: 4,818.4 g/mol
• Formula: C₂₁₀H₃₅₉N₅₇O₇₁
• Purity: Min. 95%