Palbinone
CAS: 139954-00-0
Ref. 3D-PFA95400
| 1mg | 801.00 € | ||
| 2mg | 1,160.00 € | ||
| 5mg | 1,855.00 € | ||
| 10mg | 2,898.00 € | ||
| 25mg | 5,217.00 € |
Product Information
- (3Beta,5Alpha,8Xi,14Xi)-3,17-Dihydroxy-4,4,8,10,14-Pentamethylgona-11,13(17)-Diene-15,16-Dione
- (3β,5α)-3,17-Dihydroxy-4,4,8,14-tetramethyl-18-norandrosta-11,13(17)-diene-15,16-dione
- 18-Norandrosta-11,13(17)-diene-15,16-dione, 3,17-dihydroxy-4,4,8,14-tetramethyl-, (3beta,5alpha)-
- 18-Norandrosta-11,13(17)-diene-15,16-dione, 3,17-dihydroxy-4,4,8,14-tetramethyl-, (3β,5α)-
- (-)-Palbinone
Palbinone is a molecule that blocks the activity of PI3K, an enzyme involved in insulin resistance. Palbinone has potent inhibitory activity against insulin resistance in various cell lines and is a potential antidiabetic agent. This molecule also inhibits inflammatory diseases, such as rheumatoid arthritis, by blocking NF-κB activation in macrophages. Palbinone binds to the dinucleotide phosphate (NDP) site on PI3K, which leads to inhibition of downstream signaling pathways such as the PI3K/Akt pathway. Palbinone also inhibits insulin-stimulated glucose uptake and activates AMPK in adipocytes and skeletal muscle cells, leading to reductions in body weight gain and fat mass accumulation.
Chemical properties
Technical inquiry about: 3D-PFA95400 Palbinone
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