Humanin

CAS: 330936-69-1

Ref. 3D-PHN-4384-V

Product Information

• Name: Humanin
• Synonyms: Met-Ala-Pro-Arg-Gly-Phe-Ser-Cys-Leu-Leu-Leu-Leu-Thr-Ser-Glu-Ile-Asp-Leu-Pro-Val-Lys-Arg-Arg-Ala, 1-24-Proteinhumanin (human), 188: PN: US20090053203 SEQID: 188 claimed protein, 1: PN: JP2006213632SEQID: 1 claimed protein, 1:PN: WO2009040017 PAGE: 98 claimed protein, 2: PN: WO03045988 SEQID: 2 claimedsequence, 317: PN:WO2005051988 SEQID: 317 claimed protein, 369: PN: WO0176532 SEQID: 91 claimedprotein, 48: PN: WO0181361 SEQID: 47 claimed protein, 4: PN: WO2008115525 SEQID: 188claimed protein, 60: PN:WO2008058016 SEQID: 60 claimed protein, 7: PN: WO0121786 SEQID: 5 claimedsequence, Humanin(human clone CG202524-01), Protein (human clone 1 humanin sequence homolog), Protein Humanin (human), T lymphocyte activation-associated protein PRO86272(human), Humanin Trifluoroacetate, 1: PN: US20060100253 SEQID: 1 unclaimed sequence, Humanin (human), 3: PN: WO03106683 SEQID: 3 claimed sequence, 5: PN: WO0121787 SEQID: 5 claimed sequence, 40: PN: WO2004047728SEQID: 7249 claimed sequence, 4:PN: WO2006019365 SEQID: 4 claimed sequence, 2: PN: WO2009117596 SEQID: 1 unclaimed sequence, 7: PN: WO2009135165 SEQID: 14 unclaimed sequence

Description

Encoded for by mitochondrial DNA, Humanin is an endogenous peptide known to be a ‘rescue factor’ with the ability to abolish neuronal cell death. This characteristic has promoted Humanin as a potential treatment for Alzheimer’s disease. Another function of Humanin is it can inhibit mitochondira-dependent apoptosis through preventing the formation of apoptotic bodies and the release of Cytochrome C.
Humanin has been found to be related to aging related cardiovascular disease (ACVDs) due to evidence of Humanin serum levels as age increases. Furthermore Humanin increases the expression of antioxidant defense system proteins and impedes complexes I and III from their activity in the electron transport chain in myocardial cells and mitochondria, therefore decreasing oxidative stress damage caused by H2O2. Humanin further reduces reactive oxygen species production and protects cardiomyocytes and fibroblasts, from oxidative stress.
Overall Humanin has a variety of protective functions such as mitochondrial homeostasis and redox systems regulation, anti-aging, prevention of myocardial fibrosis, anti-inflammation, metabolism improvement and autophagy promotion. It has also been found to improve beta-cell survival and thus can be used as a diabetes treatment due to it improving insulin secretion and resistance. This product is available as a 0.5mg vial.

• Brand: Biosynth

Chemical properties

• Molecular weight: 2,687.2 g/mol
• Formula: C₁₁₉H₂₀₄N₃₄O₃₂S₂
• Purity: Min. 95%