Product Information
- 1H-Pyrrole-2,5-dione, 3-[(3-chloro-4-hydroxyphenyl)amino]-4-(2-nitrophenyl)-
- Sb 415286
- 3-[(3-Chloro-4-hydroxyphenyl)-amino]-4-(2-nitrophenyl)-1H-pyrrol-2,5-dione
- 3-[(3-Chloro-4-hydroxyphenyl)amino]-4-(2-nitrophenyl)-1H-pyrrole-2,5-dione
- 3-[(3-Chloro-4-hydroxyphenyl)amino]-4-(2-nitrophenyl)-1H-pyrrole-2,5-dione
SB-415286 is a small molecule inhibitor of GSK-3β. It prevents phosphorylation of the substrate by GSK-3β, thereby preventing the inhibition of downstream signaling pathways, such as those that regulate energy metabolism and neuronal death. SB-415286 has been shown to inhibit 3t3-l1 preadipocytes differentiation into adipocytes, although it does not inhibit proliferation or stimulate apoptosis. This agent also inhibits neuronal death in axons and axon regeneration in t-cell lymphomas, suggesting that this drug may be useful for treating diseases like Alzheimer's disease or stroke.
Chemical properties
Technical inquiry about: 3D-PKA21823 SB-415286
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