Product Information
- Pro-Leu-Gly-NH2 • ½H2O
- 2-Pyrrolidinecarboxamide, N-[1-[(carbamoylmethyl)carbamoyl]-3-methylbutyl]-
- 26: PN: US6093797 PAGE: 15 claimed protein
- 27: PN: US6093797 PAGE: 15 claimed protein
- 2: PN: WO2009039992 PAGE: 107 claimed protein
- 7-9-Oxytocin
- <span class="text-smallcaps">L</smallcap>-Proline-<smallcap>L</span>-leucine-glycine-amide
- <span class="text-smallcaps">L</smallcap>-Prolyl-<smallcap>L</span>-leucyl-glycine amide
- <span class="text-smallcaps">L</smallcap>-Prolyl-<smallcap>L</span>-leucylglycinamide
- <span class="text-smallcaps">L</smallcap>-Prolyl-<smallcap>L</span>-leucylglycylamide
- See more synonyms
- Glycinamide, <span class="text-smallcaps">L</smallcap>-prolyl-<smallcap>L</span>-leucyl-
- H-Pro-Leu-Gly-NH2
- H-Pro-Leu-Gly-NH<sub>2</sub>
- L-Prolyl-L-leucylglycinamide, hemihydrate
- L-prolyl-L-leucylglycinamide
- MSH-release inhibiting factor I
- Melanocyte-Stimulating Hormone-Release Inhibiting Factor
- Melanocyte-stimulating hormone release-inhibiting factor 1
- Melanocyte-stimulating hormone release-inhibiting factor I
- Melanocyte-stimulating hormone release-inhibiting factor I (ox)
- Melanostatin I (ox)
- Mif-1
- Mif-I
- Oxytocin C-terminal tripeptide
- Pro-Leu-Gly-NH<sub>2</sub>
- Prolyleucyl-glycinamide
- Prolylleucylglycine amide
MSH-Release Inhibiting Factor (MRIF) has been shown to be a potent inhibitor of the release of proinflammatory cytokines. It is derived from the acid methyl ester of mouse serum, and has been shown to inhibit the release of tumor necrosis factor-α (TNF-α) in animal studies. MRIF has also been shown to have anti-diabetic effects in mice. MRIF inhibits the production of inflammatory cytokines by blocking TNF-α at a molecular level. This protein binds to progesterone receptor and prevents it from interacting with its ligand, which is necessary for cancer cell growth. The expression system for this protein is E. coli, and it can be used as an immunosuppressant in animal studies.
MRIF also blocks TNF-α activity by inhibiting transcriptional activation of NFκB and AP-1, which are proteins that regulate gene expression.
Chemical properties
Technical inquiry about: 3D-PMI-4024 MSH-Release Inhibiting Factor
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